Phospholipase D Is Essential for Keratocyte-like Migration of NBT-II Cells
نویسندگان
چکیده
منابع مشابه
DNase II is a member of the phospholipase D superfamily
MOTIVATION DNase II is an endodeoxyribonuclease involved in apoptosis and essential for the mammalian development. Despite the understanding of biochemical properties of this enzyme, its structure and relationships to other protein families remain unknown. RESULTS Using protein fold-recognition we found that DNase II exhibits a catalytic domain common to the phospholipase D superfamily. Our m...
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PLD (phospholipase D) activity catalyses the generation of the lipid messenger phosphatidic acid, which has been implicated in a number of cellular processes, particularly the regulation of membrane traffic. In the present study, we report that disruption of PLD signalling causes unexpectedly profound effects on the actin-based motility of Dictyostelium. Cells in which PLD activity is inhibited...
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ژورنال
عنوان ژورنال: Cell Structure and Function
سال: 2008
ISSN: 0386-7196,1347-3700
DOI: 10.1247/csf.07042